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wrote in the abstract: “The attack will cause that caused the worst disruption was aspartate. The flu
less and less hemoglobin that can carry oxygen Aspartate is a very good model for how glypho- vaccine has
and carbon dioxide. The lung cells are toxic and sate would behave because, like glyphosate, it is
inflammatory due to the inability to exchange considerably larger than glycine and negatively not been
carbon dioxide and oxygen frequently, which charged. Turning the molecule into a peroxidase successful
eventually results in ground-glass-like lung im- would result in the release of redox-active fer- in fighting
ages. The mechanism also interfered with the ryl iron (Fe(IV)), a highly oxidized and very
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normal heme anabolic pathway of the human dangerous form of iron. off flu, and
body, expecting to result in human disease.” This predicted effect is borne out in evi- there is no
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However, a rebuttal paper appeared shortly dence from people who have a genetic muta- reason to
thereafter, providing a long list of arguments tion in G139. A paper that is well summarized
why the theoretical ideas proposed by the first by its title described a patient who picked up believe that a

set of authors did not support their hypothesis a bad copy of HO-1 from both parents (a ho- coronavirus
and claiming that there is no experimental evi- mozygous change from glycine to valine). The vaccine
dence that this can happen. title is: “Mutating heme oxygenase-1 into a
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Severe hyperinflammation is perhaps the peroxidase causes a defect in bilirubin synthesis would have a
best descriptor for acute Covid-19. When some associated with microcytic anemia and severe high success
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Covid-19 cases cascade into a hyperinflamma- hyperinflammation.” The consequences of rate either.
tory state, heme is released from hemoglobin glyphosate perturbing HO-1 by substituting for
and then iron is released from heme. The highly G139 are catastrophic. Normally, HO-1 resolves
reactive free iron combined with the inflamma- inflammation, but the opposite happens when
tory response leads to widespread damage to the glyphosate disrupts the protein, setting in mo-
artery walls. This induces an acute thrombotic tion a dangerous positive feedback loop where
response, with blood clots appearing throughout inflammation induces HO-1, which induces
the vasculature, eventually leading to multiple more inflammation.
organ failure and death. A final blow comes during the massive
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If the virus is not causing this inflamma- thrombotic response triggered by damage to the
tory cascade, then what is? The answer comes walls of the blood vessels by the ferryl iron and
from studies on mutations in the enzyme heme the oxidizing agents. Thrombin is the enzyme
oxygenase 1 (HO-1). Normally, this enzyme that produces fibrin, the main component of
is able to metabolize heme into biliverdin and blood clots. Normally, antithrombin suppresses
subsequently bilirubin, releasing ferrous iron blood clot formation by binding to thrombin and
that is then sequestered inside ferritin molecules, disabling it. Severe Covid-19 disease is charac-
preventing the iron from damaging the tissues. terized by elevations in D-dimer, a marker for
Studies show that HO-1 is usually protective of thrombin overproduction. Studies have shown
oxidative stress, and, indeed, inflammation in- that antithrombin administration is beneficial
duces increased synthesis of HO-1. Importantly, to treat sepsis and that it lowers the levels of
the enzyme contains two critical glycine resi- D-dimer. Significantly, antithrombin’s activity
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dues—G139 and G143—that bind electrostati- increases over a thousand-fold through binding
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cally to heme and secure it in place to allow the to heparan sulfate or heparin. Heparan sulfate
reaction to take place. If either of these glycines synthesis is severely disturbed by glyphosate, as
is mutated to a different amino acid, the enzyme I have described together with collaborators in
can no longer successfully carry out its reaction. previous papers.
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The title of a paper published in 2000 clearly It is plausible that the rapid rollout of 5G
states the consequences of replacing the first may work synergistically with glyphosate to
glycine residue with a different amino acid: “Re- enhance the effects on iron homeostasis. Several
placement of the distal glycine 139 transforms papers have shown evidence that electromag-
human heme oxygenase-1 into a peroxidase.” netic fields (EMFs) disrupt iron status through
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The researchers replaced the first glycine residue alterations in the iron chelator ferritin, the iron
with several different amino acids, but the one regulator hepcidin or iron itself. 52-55

SUMMER 2020 Wise Traditions 35